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Diethycarbamizine (DEC) Discussion
乙胺嗪 用法 pdf side effect: Fever, headache and body aches started between 2 and 24 h after DEC intake link mode of action: “The interpretation most consistent with existing data is that DEC alters arachidonic acid metabolism in microfilariae and in host endothelial cells. These changes may result in vasoconstriction and amplified endothelial adhesion leading to immobilization of microfilarial parasites, enhanced adherence and cytotoxic activity by host platelets and granulocytes. These events would represent activation of the innate, non-specific immune system, independent of the adaptive, antigen-specific, immune response.” link Ivermectin Ivermectin fact sheet - Emory university http://www.dar.emory.edu/pi/ivermectin.pdf The Pharmacokinetics and Interactions of Ivermectin in Humans—A Mini-review full-text Ivermectin, ‘Wonder drug’ from Japan: the human use perspective full-text Moxidectin Moxidectin and the avermectins: Consanguinity but not identity Int J Parasitol Drugs Drug Resist. 2012 Dec; 2: 134–153 full text ParasitesPesticidesProduce pesticides residue (in Chinese, but good info)
Efficacy assessment of biocides or repellents for the control of Sarcoptes scabiei in the environment Fang et al. Parasites & Vectors (2015) 8:416 full text
Mode of Action Chart bioworksinc |
Drugs factsHuman whipworm (Trichuris trichiura) Giant roundworm (Ascaris lumbricoides) It is known that the combination of IVM with albendazole is more efficacious against Trichuris trichiura than albendazole alone (Belizario et al., 2003) and that IVM also has activity against Ascaris lumbricoides (Stepek et al., 2006). IVM has also proved efficacious for the treatment of strongyloidiasis and scabies in humans (Stepek et al., 2006; Sharma and Singal, 2011). To interrupt the transmission of onchocerciasis in humans, the combination of ivermectin and doxycycline is highly effective as, in infested patients, the ingestion of the anthelmintic (200 μg/kg, single dose) and the antibacterial (100 mg/kg, daily for 6 weeks), kept the microfiladermia levels low more time than did ivermectin alone. Doxycycline enhanced ivermectin-induced suppression of microfiladermia, as it sterilize adult female worms for a few months by depletion of symbiotic endobacteria of filariae, Wolbachia spp. (24) (essential for their survival and reproduction). After oral administration of 500ug/kg on human: IVM in plasma was detected for 8-10 days, MOX in plasma was detected for over 40days. Altering body composition in these animals had no detectable influence on the kinetic disposition of IVM, but MOX was distributed within and eliminated from the lean animals more rapidly than from the fat animals (Craven et al., 2001, 2002). Different MLs have different toxicity, not only in their target parasites but also in mammals, and ABM is known to be more toxic, and MOX less toxic when compared with IVM. Diethylcarbamazine (DEC) should be taken immediately after meals. Pesticides factsDEET 25% medium survival time for scabies is 20 minutes.
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